Q.) Mannitol true statements are-
a. This should be given to all patients with head injury and a reduced GCS
b. It is a loop diuretic similar in action to furosemide
c. It decreases cerebral blood flow by reducing blood viscosity and microcirculatory resistance
d. It may produce renal failure or hypotension if given in large doses
a. This should be given to all patients with head injury and a reduced GCS
b. It is a loop diuretic similar in action to furosemide
c. It decreases cerebral blood flow by reducing blood viscosity and microcirculatory resistance
d. It may produce renal failure or hypotension if given in large doses
Ans: D
Mannitol is an
osmotic diuretic that may be useful in patients with deepening coma, pupil
inequality or deterioration in neurological function. It is an osmotic diuretic
that reduces cerebral oedema by preventing movement of water from the vascular
space into the cells via the creation of an osmotic gradient. This reduces
brain volume and may prevent herniation by allowing more space for swelling or
an expanding haematoma. It also has other neuroprotective effects, promoting
cerebral blood flow and scavenging free
radicals.
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