OVARIAN TUMORS, CELLS & MARKERS

OVARIAN TUMOURS

MC Ovarian Cancer : Papillary Serous CA > Mucinous CA > Dermoid cyst > Fibroma

MC Ovarian tumor seen is females < 20yrs - Dysgerminoma

MC Ovarian tumour diagnosed during pregnancy - Dysgerminoma

MC Ovarian tumour in pre-pubertal girls - Embryonal Carcinoma


MC Ovarian tumour after menopause - Theca cell tumour

MC hormonally active Ovarian tumour - Granulosa Cell tumour

MC Epithelial Ovarian tumour - Papillary Serous CA

First s/o mets in EOT (epi ovarian tmrs) - Pelvic peritoneum

MC s/o lymphatic spread in EOT - Para - aortic and sup-gastric LNs

MC s/o haematogenous spread in EOT - Lungs

MC benign Germ cell tumour (GCT) - Benign Cystic teratoma

MC m'gnt GCT - Dysgerminoma

Ovarian tumour which spreads to opposite ovary - Dysgerminoma

Ovarian tumour in which opp ovary is involved by mets - Granulosa cell tumour

Most radiosensitive Ovarian tumour - Dysgerminoma

MC Ovarian tumour of C.T Ovary - Fibroma

MC Ovarian tumour a/w Meig's syndrome - Fibroma

MC Ovarian tumour a/w Pseudo meig's syndrome - Brenner's tumour + Granulosa cell tumour

MC s/o Primary causing secondaries in Ovary - GIT (pylorus , colon and rarely small bowel)

MC primary causing Krukenberg tumour - Stomach -lesser curvature

Ovarian tumours - special histological characteristics

Psammoma bodies - Serous CA

Hobnail cells - Clear cell Ca ovary (mesonephroid)

Walthard cell rests - Brenner's tumour

Puffed wheat appearance (m'gnt cells with a longitudinal groove ) - Brenner's tumour

Schiller -duvall bodies - Endodermal sinus tumour / yolk sac tumour

Reinke crystalloids - Leydig cell tumour / Hilus cell tumour

Call - Exner bodies - Granulosa cell tumour

Signet ring cells - Krukenberg tumour



Tumour markers :

CA- 125 - Non mucinous ECT

CA -19.9 - Mucinous ECT

CEA - Mucinous adenocarcinoma

AFP - Embryonal cell carcinoma & Endodermal sinus tumour

hCG - Embryonal cell carcinoma & Choriocarcinoma

LDH - Dysgerminoma

alpha -1 AT - Endodermal sinus tumour


Monoclonal Ab for detection of Ovarian carcinoma - OVLT -3


Feminising Ovarian tumours:

Granulosa cell tumour
Theca cell tumour
Luteoma

Virilising ovarian tumours :

Sertoli cell tumour/arrhenoblastoma
Adrenal cortical tumour
Hilus cell tumour


Characteristics of both Granulosa cell tumour and Arrehnoblastoma - Gynandroblastoma


Non-endocrine secreting tumour of Ovary - Dysgerminoma & Fibroma